T Cell

Tools for the identification, isolation, and multicolor analysis of human regulatory T cells

As published data on the immunosuppressive potential of regulatory T cells (Tregs) has accumulated, enthusiasm for their potential therapeutic application has intensified. As a result, Treg research is very active, and new publications emerge almost daily. Today the most commonly used markers for Treg identification, isolation, and characterization are CD4, CD25, CD127, and FoxP3. However, new targets with functional significance such as CD39, CD45RA, CTLA-4, and others are rapidly emerging.

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